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- W2384703652 abstract "Objective To study the appropriate range of arterial blood partial pressure of carbon dioxide (PaCO2) in permissive hypercapnia ventilation in the treatment of neonatal respiratory distress syndrome(NRDS). Methods From Jan.2004 to Dec.2009 in Sanming First Hospital Affiliated to Fujian Medical University,90 cases of infants who were treated with mechanical ventilation were randomly divided into three groups: control group(PaCO2 range 35～45 mmHg)(1 mmHg = 0.133 kPa),treatmentⅠgroup(PaCO2 range 46～60 mmHg),treatment Ⅱgroup(PaCO2 range 61～75 mmHg). Data relevant to the neonates were collected and analyzed ,including the ventilator’s parameter ,blood gas ,complications and therapeutic effectiveness. Results Mean airway presure (MAP),inspiratory time (Ti) and peak inspiratory presure (PIP) in the treatment group were significantly lower than those in the control group respectively (P 0.01);fraction of inspiration O2(FiO2)was lower than that in the control group (P 0.05);respiratory rate(RR) was higher than that in the control group (P 0.05);pH in treatment group was lower than that in the control group (P 0.05);PaCO2 was significantly higher than that in the control group(P 0.01);PaCO2 in the treatmentⅠgroup was significantly lower than that in the treatment Ⅱ group (P 0.01); the incidence of ventilator associated lung injury (VALI) in treatment groups was lower than that in the control group (P 0.05),and mechanical ventilation time was significantly lower than that in the control group (P 0.01);the therapeutic effectiveness was better than that of the control group (P 0.05). There were also no differences in the length of hospitalization ,incidence of intraventricular hemorrhage(IVH) and periventricular leukomalacia(PVL)(P 0.05),but consequence of IVH in the control group and the treatment Ⅱ group was very serious. Conclusion Permissive hypercapnia ventilation in the treatment of NRDS can markedly decrease the incidence of VALI and mechanical ventilation time,without affecting oxygenation,heart rate,blood pressure and without increasing the incidence of IVH and PVL;the therapeutic effectiveness is better than that of the conventional mechanical ventilation.Moderate range of PaCO2(46～60 mmHg) is appropriate because of slight IVH ." @default.
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- W2384703652 date "2012-01-01" @default.
- W2384703652 modified "2023-09-23" @default.
- W2384703652 title "Appropriate range of arterial blood partial pressure of carbon dioxide in permissive hypercapnia ventilation" @default.
- W2384703652 hasPublicationYear "2012" @default.
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