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- W2384707931 abstract "Objective To observe the changes of expressions of glucose transporter 1,3 gene(GLUT1 mRNA and GLUT3 mRNA) in hippocampus after hypoxic-ischemic brain damage in newborn rats and effects of progesterone on them.Methods Forty SD rats(7-day-old) were divided randomly into 4 groups:normal group,sham operation group,hypoxic-ischemic group and progesterone group.Rats were subjected to right common carotid artery ligation and exposed to 80 mL/L oxygen and 920 mL/L nitrogen gas for 2 hours to establish hypoxic-ischemic model in hypoxic-ischemic group and progesterone group.The rats in sham operation group only received right common carotid artery ligation.Progesterone(8 mg/kg) or sesame oil(of same volume) was given intraperitonealy in progesterone group or other groups 30 minutes before operation.All rats were killed 24 hours after operations.The expressions of GLUT1 mRNA and GLUT3 mRNA in hippocampus of rats in every group were assessed by adopting RT-PCR technique.Results The expressions of GLUT1 mRNA and GLUT3 mRNA in the hypoxic-ischemic group(0.674±0.083,0.785±0.093) increased markedly compared with those in sham operated group(0.374±0.061,0.519±0.060)(Pa0.01).The expressions of GLUT1 mRNA and GLUT3 mRNA in the progesterone group(0.957±0.077,1.138±0.090) increased markedly compared with those in the sham operation group(0.374±0.061,0.519±0.060) and hypoxic-ischemic group(0.674±0.083,0.785±0.093)(Pa0.01).The expressions of GLUT1 mRNA and GLUT3 mRNA between the normal group(0.363±0.063,0.503±0.085) and sham operation group(0.374±0.061,0.519±0.060)had no significant difference(Pa0.05).Conclusions Progesterone maintain the energy supply of the brain by up-regulating the expression of GLUT1 mRNA and GLUT3 mRNA and accelerating the transportation of glucose into brain,which may be one of the protective mechanisms." @default.
- W2384707931 created "2016-06-24" @default.
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- W2384707931 date "2009-01-01" @default.
- W2384707931 modified "2023-09-25" @default.
- W2384707931 title "Expressions of Glucose Transporter 1,3 Gene in Hippocampus of Newborn Rats with Hypoxic-Ischemic Brain Damage by Progesterone Intervention" @default.
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