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- W2384713405 abstract "Objective The study went through after the irradiation of high energy electronic wires which was conducted on the experimental model of hypertrophic scar of rabbits' ears.Observed the healing process and showed the pathological change as well as the variation of actin(ACTIN) and vascular endothelial growth factor(VEGF) after the healing of the scar.Methods Selected 18 Japanese rabbits and made 10 models of circular full-thickness wound defects in the ventral side of per ear which each one was in the size of 6mm diameter.The total number of 360 wound defects was randomly divided into 6 groups.Group1 was the blank control group(3 samples),and the other 5 groups were the radiation group(3 samples in each group).Each wound defects on rabbits'ears was randomly irradiated with 200cGy,400cGy,600cGy,800cGy,1000cGy 6Mev electronic wires and the radiation field around was protected by the stereotype.Observed the change during the healing process and the progress of the scar tissue after the wound defects had already healed.Got the experimental material 1 month after the treatment injury and continued on the observations of the light microscopy,electron microscopy and histology.Results The wound defects in the ventral side of the rabbits'ears could produce the similar hypertrophic scar like human beings.Each radiation group showed that the healing of the wound defects was delayed.Under the similar amount of the radiation,different volume of radiation per time could result a significant difference on the formation of the hypertrophic scar.Conclusion Japanese rabbits' could produce the similar pathological change of hypertrophic scar like human beings,and they could be the experimental animal model for the observation on pathological scar.This experiment proofed that radiation with 6 Mev pathological electronic wires is an effective way to cure the hypertrophic scar.Under the similar amount of the radiation,radiating 5 times fractionally which measured 400 Gy each time was the best quantities." @default.
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- W2384713405 date "2012-01-01" @default.
- W2384713405 modified "2023-09-25" @default.
- W2384713405 title "Experimental study of radiation therapy for hypertrophic scar in rabbits' ears" @default.
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