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- W2384729378 abstract "Objective To observe the clinical effect of trolamine(biafine) in preventing and treating acute and chronic radiation-induced dermal injury in the head and neck carcinoma patients.Methods Seventy-two patients who accepted radiotherapy were randomized into two groups:treatment group(40 cases) was given biafine cream since the first radiotherapy session to 3-6 months after treatment while the other 32 served as control with Qingdiyou medication when general and health education program was given.Results The rate of skin reaction was 100.0% in both groups.The radiation reaction(grade Ⅰ,Ⅱ,Ⅲ and Ⅳ) was 37.5%,47.5%,5.0%,0% in the treatment group and 18.8%,31.2%,34.4%,12.5% in the control group.There was a significant difference between the two groups(P0.05).The skin response occurred after the patients received a dose of 40 Gy in the treatment group,obviously later than the control group(P0.05).The healing time of acute radiation-induced dermal injury was 6 days in treatment group,and 11 days in control group(P0.05).Three to six months after radiation,the chronic dermatofibrosis was 27.5% in treatment group,obviously lower than that in the control group(68.8%)(P0.05).Conclusion Trolamine(biafine) cream can effectively prevent and cure acute and chronic radiation-induced dermal injury,and significantly delay the occurrence time and reduce the healing time of acute dermal injury." @default.
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- W2384729378 date "2011-06-10" @default.
- W2384729378 modified "2023-09-24" @default.
- W2384729378 title "Effect of trolamine (biafine) in preventing and treating radiation-induced dermal injury in head and neck carcinoma patients" @default.
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