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- W2384736242 abstract "AIM To investigate the sedative effect and safety of dexmedetomidine for chronic obstructive pulmonary disease(COPD) patients undergoing mechanical ventilation.METHODS Fifty COPD patients undergoing mechanical ventilation were enrolled and divided into dexmedetomidine group and propofol group randomly(25 in each).The loading dose and maintenance dose of dexmedetomidine was 1μg·kg~(-1) and 0.2 - 0.7μg ? kg~(-1)?h~(-1),and 1 mg·kg~(-1) and 0.5 - 4.0 mg·kg.(-1)·h~(-1) for propofol.The drug dose was adjusted according to Riker sedation-agitation scale(SAS).The SAS,revive time and the time when the SAS reach 2-3 were recorded.The length of ICU stay,ventilator weaning time,and the incidences of bradycardia,respiratory depression and delirium were compared between two groups.RESULTS All patients reached targeted sedation level and there was no difference in time between two groups.Dexmedetomidine-treated patients were more likely to wake up and keep quiet.The length of ICU stay and ventilator weaning time of the dexmedetomidine group were shorter compared with those of the propofol group((6.4±1.2) and(3.2±1.0) d vs.(8.3±1.4) and(5.1±2.3) d,P0.05).The incidences of delirium and respiratory sepression of the dexmedetomidine group were lower than those of the propofol group(4%and 4%vs.32%and 28%,P0.05) and there was no significantly difference in the incidence of bradycardia(P0.05).CONCLUSION Dexmedetomidine is an effective and safety sedative for COPD patients undergoing mechanical ventilation and can reduce the length of ICU stay and ventilator weaning time." @default.
- W2384736242 created "2016-06-24" @default.
- W2384736242 creator A5047701629 @default.
- W2384736242 date "2012-01-01" @default.
- W2384736242 modified "2023-09-23" @default.
- W2384736242 title "Feasibility of dexmedetomidine in sedation for chronic obstructive pulmonary diseases patients undergoing mechanical ventilation" @default.
- W2384736242 hasPublicationYear "2012" @default.
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