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- W2384751372 abstract "Objective: To observe the effect of bombyx batryticatus injection(僵蚕注射液) on the tissue type plasminogen activator(t-PA) and plasminogen activator inhibitor-1(PAI1) activities of human umbilical vascular endothelial cell(HUVEC) induced by thrombin.Methods: The well grown 2-5 generations of HUVECs were cultured for the study.After different concentrations of bombyx batryticatus injection(600,300 and 150 mg/L respectively) were given,the activities of PAI-1 and t-PA released by HUVEC induced by thrombin(5 kU/L) were measured with enzyme linked immunoadsorbent assay(ELISA) 12 hours after cultivation.Results: PAI-1 was increased and t-PA expression was inhibited by 5 kU/L thrombin in HUVEC compared with the blank controls without thrombin and bombys batryticatus(both P0.01).The activities of tPA were increased and the activities of PAI-1 were reduced by different concentrations of bombyx batryticatus injection compared with thrombin group(all P0.01),and the effect rates of high,middle and low doses of bombys batryticatus on t-PA in HUVEC induced by thrombin were 96.8%,95.6% and 55.1%,and those on PAI-1 were 92.5%,85.4% and 29.3%,respectively.Conclusion: High dose of bombyx batryticatus injection can significantly inhibit the HUVEC releasing function induced by thrombin and inhibit the coagulation process." @default.
- W2384751372 created "2016-06-24" @default.
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- W2384751372 date "2007-01-01" @default.
- W2384751372 modified "2023-09-22" @default.
- W2384751372 title "Effect of bombyx batryticatus injection(僵蚕注射液) on the balance of fibrinolytic system of human umbilical vascular endothelial cell induced by thrombin" @default.
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