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- W2384752904 abstract "Objective To study the telomerase activity and expression of C-myc gene in ovarian malignant tumors Methods From different tissue specimens, telomerase activity was detected by PCR-ELISA underlines TRAP (telomeric repeated sequences amplification protocol) Expression of C-myc was detected by RT-PCR Results Telomease activity in poorly differentiated, FIGO stage Ⅲ and Ⅳ tended to be higher than those in highly differentiated, early FIGO stages respectively ( P 0 05, P 0 05) There was no significant correlation among the positive rate of telomerase and histological types and histological grades( P 0 05) Telomerase activity was not detectable in normal ovaries C-myc was detectable in 20 samples out of 73 Telomerase activity in this group was higher than C-myc negative group ( P 0 05) Conclusions Telomerase activity is a useful marker of diagnosis,predicting prognosis and evaluating treatment of patients with malignant ovarian tumors Expression of C-myc gene might be related to the activation of telomerase which attributes the progression of ovarian malignant tumors" @default.
- W2384752904 created "2016-06-24" @default.
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- W2384752904 date "2003-01-01" @default.
- W2384752904 modified "2023-09-24" @default.
- W2384752904 title "The activity of telomerase and expression of C-myc gene in ovarian tumors" @default.
- W2384752904 hasPublicationYear "2003" @default.
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