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- W2384773275 abstract "Objective:To investigate the roles of erythropoietin receptor(EPOR) in the mechanism of erythrocytosis at high altitude.Methods:Adult Wistar rats were randomly divided into 4 groups: normal group(normoxia) and other 3 groups that were exposed to simulated high altitude(above seal level 5 000 m) for 5 days,15 days and 30 days,respectively.~(125)I-EPO was used to demonstrate expression of saturable high affinity binding sites for EPO in rat bone marrow cells.Results:Compared with the normoxia group,the affinity of EPOR in rat bone marrow cells increased in 5-day groups,and declined in 15-day and 30-day groups(P0.01).Binding sites per cell showed an increased trend along with hypoxic process.Conclusion:The increases of affinity and quantity of EPOR in rat bone marrow cells induced by hypoxia plays an important role in the development of erythrocytosis at first,but at later stage other factors maybe play more important role in the development of erythrocytosis." @default.
- W2384773275 created "2016-06-24" @default.
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- W2384773275 date "2006-01-01" @default.
- W2384773275 modified "2023-09-22" @default.
- W2384773275 title "Effects of simulated high altitude on affinity and quantity of erythropoietin receptor in rats' bone marrow cells" @default.
- W2384773275 hasPublicationYear "2006" @default.
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