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- W2384775301 abstract "Objective To investigate the effects of a docosapeptide(SP22) screened by peptide library on the blockade of activity site of normal or mutant CD59 molecules highly expressed on prostate cancer cells.Methods the pIRES vectors carrying wild-type CD59 gene(wCD59) or mutant CD59 gene(mCD59) and the empty vectors pIRES were transfected into PC-3 cells respectively.The expression of CD59 on PC-3 cells was detected by fluorescence activated cell sorter(FACS),while the level of CD59 mRNA was assayed by semiquantitative RT-PCR.The effects of SP22 on the blockade of activity site of CD59 molecules was evaluated by complement lysis assays.Results pPC-3 cells into which empty vectors were transfected expressed lower level of CD59 mRNA than other two kinds of PC-3 cells.With the addition of SP22,the lysis rate of transfected cells was raised in quite different modes.Conclusion SP22 can effectively block the complement-binding sites of normal CD59 molecules and in return greatly enhance complement-mediated lysis to PC-3 cells,although it fails to bind to the mutant CD59 molecules." @default.
- W2384775301 created "2016-06-24" @default.
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- W2384775301 date "2009-01-01" @default.
- W2384775301 modified "2023-09-24" @default.
- W2384775301 title "Blockade of the activity site of CD59 molecules highly expressed on prostate cancer cells" @default.
- W2384775301 hasPublicationYear "2009" @default.
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