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- W2384778922 abstract "Objective To determine whether sonodynamic treatment(SDT) can enhance chemotherapy effect of cisplatin on ovarian cancer cells.Methods Drug resistance ovarian cancer cells COC1/DDP were divided into 4 groups randomly:cisplatin(DDP)group,haematoporphyrin(Hp)+ Ultrasound group,cisplatin(DDP)+ haematoporphyrin(Hp)+Ultrasound group and control group.Cell proliferation,apoptosis,protein bcl-2 and bax expression were observed.Results In DDP+ Hp+Ultrasound group,cell proliferation was greatly inhibited,COC1/DDP cell clone efficiency was the lowest(P0.05).Bcl-2 expression in Hp+ Ultrasound group and DDP+Hp+ Ultrasound group deceased significantly(P0.05),while there were no obvious difference in control goup and cisplatin group.We did not observe great difference in protein bax expression in any group(P0.05).Conlusion SDT could effectively enhance cell killing ability of cisplatin on drug resistance ovarian cancaer cells." @default.
- W2384778922 created "2016-06-24" @default.
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- W2384778922 date "2009-01-01" @default.
- W2384778922 modified "2023-09-23" @default.
- W2384778922 title "A Discussion on Effect and Mechanism of Haematoporphyrin to Chemotherapy Sensitivity of Cisplatin on COC1/DDP" @default.
- W2384778922 hasPublicationYear "2009" @default.
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