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- W2384779598 abstract "Objective To explore the effect of adenoviral-mediated HIF-1α gene transfer to the injured spinal cord on the expression of NGb.To provide basis for the clinical application of adenoviral-mediated HIF-1α gene transfer in the treatment of spinal cord injury.MethodsThe spinal cord injury(SCI) model of SD rats,was induced with electrocircuit control spinal cord injuring device method by a 10 g×2.5 cm impact on the posterior T13 spinal cord.Six rat spinal cords were perfused for H-E and HIF-1α,NGb immuno-histochemical staining.The immunoreactivities of HIF-1α,NGb in spinal cord were measured and analyzed using LEICA QWin image processing and analysis system.ResultsIn Normal and Sham groups,the expression of NGb located in the ventral horn was moderate,whereas loftily in SCI,Ad-Blank and Ad-HIF-1α groups and reached the peak at 7 d in Ad-HIF-1α group.The OD of Ad-HIF-1α was prominently higher than that of SCI and Ad-Blank.ConclusionsAdenoviral-mediated HIF-1α gene therapy can prompt the expressions of NGb and BDNF after spinal cord injury.That suggested NGb gene is Hypoxia Response gene(HRG)." @default.
- W2384779598 created "2016-06-24" @default.
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- W2384779598 date "2007-01-01" @default.
- W2384779598 modified "2023-09-25" @default.
- W2384779598 title "The Expressions of NGb after Adenoviral-mediated HIF-1α gene Therapy for Spinal Cord Injury in Rat" @default.
- W2384779598 hasPublicationYear "2007" @default.
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