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- W2384796685 abstract "Objective To observe the effect of L-lysine monohydrochloride (LMH) on pancreatic islet B cells, the levels of endogenous insulin and blood sugar levels in the injured spinal cord of rats.Methods The rats were randomly divided into four groups, the healthy control group, the spinal cord injury group, the LMH1 group and the LMH2 group.The rat model was produced by hemi-transection at the lower right thoracic spinal cord aseptically.Peritoneal injection of LMH was adopted among the rats in the LMH1 group and the LMH2 group at 621.5, 310.8 mg/kg respectively for once.Equivalent normal saline was injected into the rats of the spinal cord injury group.Results The immunohistochemical reactions of positive B cells were significantly weaker in the spinal cord injured group than in the control group (P0.01).The levels of endogenous insulin were significantly lower and the blood sugar levels were significantly higher in the spinal cord injured group than in the control group (P0.01).The immunohistochemical reactions of positive B cells were significantly stronger in LMH group than in the spinal cord injured group (P0.05) ; the levels of endogenous insulin were significantly higher and the blood sugar levels were significantly lower in LMH1 group (621.5 mg/kg) than in the spinal cord injured group (P0.05).The immunohistochemical reaction of positive B cells, the levels of endogenous insulin and the blood sugar levels had no significant difference in LMH2 group (310.8 mg/kg) compared with that in the spinal cord injured control group (P0.05).Conclusions The results indicate that LMH might participate in the regulation of B cells of pancreatic islet and thus the decrease of blood sugar level in the spinal cord injured rats." @default.
- W2384796685 created "2016-06-24" @default.
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- W2384796685 date "2010-01-01" @default.
- W2384796685 modified "2023-09-23" @default.
- W2384796685 title "Effect of L-lysine monohydrochloride on pancreatic islet and blood sugar levels in the spinal cord injured rats" @default.
- W2384796685 hasPublicationYear "2010" @default.
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