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- W2384801511 abstract "AIM:To evaluate the role of anti-depression drug trazodone on functional dyspepsia (FD). METHODS: Forty female patients of FD received trazodone treatment for 6 wk (trazodone group) and other 40 received placebo at the same time (placebo group) and some healthy people were served as the control group. Hamilton depression scale (HAMD) and water loading test (WLT) were used to evaluate the psychological conditions and gastric functions of all healthy controls and FD patients before and after the treatment. RESULTS: Both HAMD scores of pre-cure trazodone group (23±s 5) and pre-cure placebo (21±5) were significantly higher than that of healthy control group (3.8±2.8, each P 0.01). Both WLT quantity of pre-cure trazodone group (918±164) mL and pre-cure placebo group (919±210) mL were significantly lower than that of healthy control group ((1 853±190) mL, each P 0.01); with a significant difference of HAMD score and WLT quantity between pre-cure trazodone group and post-cure trazodone group (each P 0.01). The symptom score of pre-cure trazodone group (6.5±1.4) was much higher than that of post-cure trazodone group (3.4±1.9, P 0.01). For the placebo group, the symptom score of pre-cure (6.4±1.7) was much higher than that of the post-cure (5.6±1.7, P 0.01). The symptom score of post-cure trazodone group was lower than that of post-cure placebo group (P 0.01) . All functional dyspepsia patients presented with a negative correlation between HAMD score and WLT quantity (each P 0.05). CONCLUSION: Trazodone possesses a significant ability in improvement depressive symptoms and gastric accommodation function for FD patients with actually relieve of FD symptoms including bloating, abdominal pain, and early satiety." @default.
- W2384801511 created "2016-06-24" @default.
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- W2384801511 date "2007-01-01" @default.
- W2384801511 modified "2023-09-23" @default.
- W2384801511 title "Anti-depression drug trazodone in treating 40 female patients with functional dyspepsia" @default.
- W2384801511 hasPublicationYear "2007" @default.
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