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- W2384816510 abstract "Objective To evaluate the effect of dendritic cells(DC)sensitized by Exosomes in the treatment of advanced colorectal cancer.Methods One hundred and five patients with advanced colorectal cancer were randomly divided into combination treatment group(chemotherapy +DC sensitized by Exosomes)(n=65)and chemotherapy group(n=50)for observation of the T cell subsets in peripheral blood,response rate,one year survival rate,median survival time and toxicity.Results CD3+、CD4+ and CD8+ in combination treatment group after treatment were improved(P0.05),which was also superior to chemotherapy group(P0.05).Response rates were 56.9% in combination treatment group and 38.0% in chemotherapy group(P0.05).One year survival rate and median survival time were 66.7% and 15.6 months,respectively,in patients allocated to combination treatment group compared with 52.1% and 12.3 months,respectively,in patients allocated to chemotherapy group(P0.05 for both comparisons).There was no significant difference in toxicity between both groups(P0.05).Conclusion Dendritic cells sensitized by Exosomes combined chemotherapy is well effective and tolerated in the treatment of advanced colorectal cancer,improve immunity function and prolong survival period." @default.
- W2384816510 created "2016-06-24" @default.
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- W2384816510 date "2009-01-01" @default.
- W2384816510 modified "2023-09-23" @default.
- W2384816510 title "Clinical application study of dendritic cells sensitized by Exosomes in the treatment of advanced colorectal cancer" @default.
- W2384816510 hasPublicationYear "2009" @default.
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