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- W2384820161 abstract "Objective To evaluate the significance of plasma D (-)-lactate,diamine oxidase (DAO) and endotoxin activities in the patients with liver cirrhosis.Methods Fifty patients with cirrhosis were employed as experimental group while 30 healthy people as control group.The plasma concentrations of D (-)-lactate,DAO and endotoxin were detected by spectrophotography.Results The concentration of D (-)-lactate in experimental group was significantly higher than that in the control group(P0.01),there were significant differences of D(-)-lactate levels among different Child-Pugh class(P0.01).After therapy,D(-)-lactate level in experimental group decreased significantly(P0.01).The concentration of DAO in experimental group was significantly higher than that in the control group(P0.01),but in Child-Pugh C group it was significantly lower than that in Child-Pugh B group(P0.01).After therapy,DAO levels in Child-Pugh B and A groups decreased significantly(P0.05),but increased in Child-Pugh C group(P0.05).The level of endotoxin in experimental group had obviously increased except Child-Pugh class A(P0.01).After therapy,endotoxin level decreased significantly in Child-Pugh C group(P0.01).The plasma levels of D(-)-lactate,DAO and endotoxin were positively correlated with each other(P0.01).Conclusion Both plasma D(-)-lactate and DAO activities were sensitive markers for early diagnosis of gut failure and endotoxemia in cirrhosis patients.The impairment of intestinal barrier function may be one of the critical reasons for cirrhosis deterioration." @default.
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- W2384820161 date "2004-01-01" @default.
- W2384820161 modified "2023-09-22" @default.
- W2384820161 title "Determination of plasma D(-)-lactate,diamine oxidase and endotoxin and its significance in the patients with liver cirrhosis" @default.
- W2384820161 hasPublicationYear "2004" @default.
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