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- W2384837188 abstract "Objective:To study the clinical effects of patient-controlled epidural analgesia(PCEA)on postoperative pain and the serum interleukins level(IL-2 and IL-6)in patients with cancer.Methods:Thirty ASAⅠ-Ⅱ patients aged 20-60 with gynecological malignancy undergoing radical correction were selected and randomly divided into two groups(15 patients each group):buprenorphine group(group B)and fentanyl group(group F).PCEA were administrated after surgery continued for 48h.Blood samples were taken from peripheral vein 2h before anesthesia,1d,3d and 5d after surgery for determination of serum IL-2 and IL-6 level using enzyme-linked immunosorbent assay(ELISA).The analgesic effect was assessed by VAS score.The incidence of side effects was recorded.Results:The postoperative analgesia was good in both groups.Compared with that before anesthesia(base line),there was no significant difference in IL-2(P0.05)and no difference between the two groups(P0.05).IL-6 level in both group noticeably raised 2h after surgery compared with base line(P0.01),gradually decreased 1d and 3d after analgesia comparing with 2h after surgery(P0.01),but was higher than base line(P0.05),on the 5th day after surgery essentially recovered to base line(P0.05);But there was no difference between the two groups(P0.05).Conclusion:PCEA with eliminate postoperative pain on patient with cancer undergoing radical correction.The two drugs have little effect on serum IL-2 level,but decrease the elevated IL-6 level.Buprenorphine and fentanyl used in patients with gynecological malignancy may alleviate the stress response,attenuate immunosuppression and expedite recovery after surgery." @default.
- W2384837188 created "2016-06-24" @default.
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- W2384837188 date "2009-01-01" @default.
- W2384837188 modified "2023-09-24" @default.
- W2384837188 title "Influence of postoperaive pcea on IL-2 and IL-6 in patients with cancer" @default.
- W2384837188 hasPublicationYear "2009" @default.
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