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- W2384850005 abstract "Objective To investigate the appropriate HPLC detection for studying the stability of esomeprazole(Eso) sodium for injection with six kinds of common solvents,and thus provide an evidence for using reasonable compound preparation in clinical use.Methods The Eso sodium for injection was compatible with 100 mL six kinds of common solvents respectively,and the pH value was detected.The content of Eso sodium in the compatible solution was analyzed by HPLC.The color and clarity were observed at regular time.Results Eso showed a good linear relationship within the range of 0.05-1.60 mg·mL-1(R2=0.999 9).There were no significant changes on pH value,color,clarity and content within 24 h after being mixed with 0.9% sodium chloride injection and xylitol one.No distinct changes appeared 12 h,8 h and 6 h after being mixed with 10%GS,5%GS,5%GNS injection,and the Eso solutions of which were relatively stable.While,the situation was different for Eso mixed with fructose injection.Conclusion Eso is incompatible with fructose injection and shows better compatibility with 0.9% NS or 5% xylitol injection.The drip of admixture should be finished within12 h,8 h and 6 h when mixing with 10%GS,5%GS,5%GNS,respectively." @default.
- W2384850005 created "2016-06-24" @default.
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- W2384850005 date "2012-01-01" @default.
- W2384850005 modified "2023-09-23" @default.
- W2384850005 title "Study on Compatible Stability of Esomeprazole Sodium for Injection with Six Kinds of Common Solvents" @default.
- W2384850005 hasPublicationYear "2012" @default.
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