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- W2384851116 abstract "Aim To explore the pharmacokinetic characteristic of sertraline in Chinese healthy male volunteers.Methods The 12 healthy volunteers were divided into receiving orally a single dose of 50,100,150 mg sertraline tablets respectively,in latin square design study.After administration of sertraline tablets,the plasma concentration were determined using UV-HPLC with solid phase extraction method.The pharmacokinetics parameters were analyzed by DAS program.Results It was found that plasma levels increased after orally increased dosage of sertraline in the healthy volunteers exhibited a dose-dependent manner.The pharmacokinetic parameters calculated were the follows: AUC_(0-96) of three different dosages(50,100,150 mg) are(437.51±80.78),(804.19±178.11) and(1154.57±243.92) μg·h·L~(-1);and C_(max) are(11.70±2.40),(22.84±7.05) and(32.61±7.95) μg·L~(-1) respectively.There were no significant differences in AUC_(0-t)/dose,C_(max)/dose between the group(P0.05).Conclusion The pharmacokinetic characteristic of sertraline in Chinese healthy volunteers(in 50~150mg process) were fitted with linear kinetic model." @default.
- W2384851116 created "2016-06-24" @default.
- W2384851116 creator A5062371490 @default.
- W2384851116 date "2006-01-01" @default.
- W2384851116 modified "2023-09-25" @default.
- W2384851116 title "Study on pharmacokinetic of sertraline in chinese healthy volunteers" @default.
- W2384851116 hasPublicationYear "2006" @default.
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