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- W2384863670 abstract "Background Loss of response (LOR) to infliximab (IFX) has become an important clinical issue for patients with Crohn’s disease (CD). Elemental diet (ED) therapy has been established as a nutrition therapy for CD in Japan. ED therapy can reduce antigen exposure and is both efficacious and safe. Aim To evaluate the efficacy of concomitant ED therapy in maintaining regular IFX infusion in patients with CD. Methods We retrospectively studied 125 patients with luminal CD treated with scheduled IFX maintenance therapy with a regular dosage. Patients were classified into two groups: the ED group with intake C900 kcal/day and the non-ED group with intake 900 kcal/day. When clinical LOR was detected on the basis of disease activity, laboratory parameters, or endoscopic findings, the physician discontinued the infusion schedule of IFX. We investigated the efficacy of ED therapy for sustaining the scheduled IFX maintenance therapy. Results With the exception of ED intake, no significant differences were found in patient characteristics between the ED group and the non-ED group. The ED group was significantly superior to the non-ED group (p = 0.049) in sustaining scheduled IFX maintenance therapy. It is well known that ED therapy is more effective for small bowel lesions than colonic lesions in CD. When comparing ileitis" @default.
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- W2384863670 date "2015-01-01" @default.
- W2384863670 modified "2023-09-26" @default.
- W2384863670 title "Efficacy of Concomitant Elemental Diet Therapy in Scheduled Infliximab Therapy in Patients with Crohn's Disease to Prevent Loss of Response" @default.
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