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- W2384868045 abstract "Objective:To observe the effect of astragaloside Ⅳ on contraction and relaxation on isolated mesenteric arteries,and to study its underlying mechanisms.Methods:The isolated mesenteric arteries segments were mounted in the Danish Myo Technology Multi Wire Myograph System(DMT).The effect of astragaloside Ⅳ on contraction and relaxation on the arteries was observed.Results:①After incubation in the solution of Astragaloside Ⅳ of different concentrations(30 mg/L and 100 mg/L),vasoconstriction induced by ethyl phenyllphrine obviously declined compared with control grou(pP0.05 or P0.01).②Astragaloside Ⅳ relaxed mesenteric artery rings(both with and without endothelium) in concentration-dependent manner,which had been precontracted with ethyl phenyllphrine(2×10-6 mol/L),while the relaxation of the rings with endothelium was significantly stronger than that of rings without endothelium( P0.05 or P0.01).③Astragaloside Ⅳ had no significant effect on those which had been precontracted by KC(lP0.05).④Pre-treatment with L-NAME(10-4 mol/L) significantly decreased the effect of vasodilatation of Astragaloside Ⅳ(P0.05 or P.01).Conclusion:Astragaloside IV can endothelium-dependently dilate vessels to some extent,and it plays this function mainly through the NO pathway." @default.
- W2384868045 created "2016-06-24" @default.
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- W2384868045 date "2008-01-01" @default.
- W2384868045 modified "2023-09-24" @default.
- W2384868045 title "Effect of astragaloside IV on contraction and relaxation on isolated rat mesenteric arteries" @default.
- W2384868045 hasPublicationYear "2008" @default.
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