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- W2384892829 abstract "AIM: To investigate the effects of the vaccine consisting of Helicobacter pylori (H.pylori) sialic acid adhesin and cholera toxin (CT) in the treatment of H.pylori infection in a H.pylori infected mouse model. METHODS: The C57BL/6 mice infected with H.pylori were divided into 4 groups. The mice of each group were immunized by sialic acid adhesin (100 μg) plus CT (2 μg), sialic acid adhesin (100 μg), CT (2 μg), PBS orally respectively, once a week for 4 weeks. Four weeks after last treatment, all animals were sacrificed and stomach biopsies were collected to detect H.pylori by the semi-quantitative bacterial culture assay. RESULTS: The eradication rate of the vaccine group was 30% (3/10). The eradication rates of the other 3 groups were all 0%. There were significant differences in the eradication rate among the vaccination group and the other 3 control groups (P0.05). In addition, the H.pylori colonized density of vaccination group was significantly lower than that of other 3 groups (P0.05). CONCLUSION: Sialic acid adhesin could be an effective component of H.pylori multi-valence vaccine." @default.
- W2384892829 created "2016-06-24" @default.
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- W2384892829 date "2008-01-01" @default.
- W2384892829 modified "2023-09-24" @default.
- W2384892829 title "Immunization treatment of Helicobacter pylori infection with the vaccine composed of sialic acid adhesin and CT: An animal model study" @default.
- W2384892829 hasPublicationYear "2008" @default.
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