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- W2384905827 abstract "Objective To observe the expression of IL-10 and metalloprotein-9 in non-small cell lung canncer and investigate their correlations to the invasion,metastasis and prognosis of NSCLC.Methods The expression level of IL-10 and MMP-9 were detected in 60 NSCLC specimens and 20 cases of benign pulmonary lesions by using immunohistochemistry with SP method.And their correlation with clinicopathological feature and prognosis were compared by using single-factor survival analysis and cox multivariate analysis.Results NSCLC showed significantly increased positivity for IL-10 and MMP-9 expression than in benign pulmonary lesions(P0.05).IL-10 expression was negatively correlated with MMP-9 expression.the survival time of low expression was shorter than the high-expression in IL-10 group,while in MMP-9 group,the low expression survival time was longer than the high-expression survival time(P0.05).TNM stging/IL-10/MMP-9 expression status are related to prognosis of NSCLC,and the high expression of IL-10 and low expression of MMP-9 may have an impact on the prognosis of NSCLC.Conclusion The expression of IL-10 and MMP-9 were impact factors of NSCLC.TNM staging /IL-10/MMP-9 expression were independent prognostic impact factors of NSCLC.High expression of IL-10 and low expression of MMP-9 were independent factors.IL-10 may inhibit metastasis of tumor cells by inhibiting the expression of MMP-9.Therefore,it may play an important role to assess the prognosis of NSCLC patients by monitoring the expression of IL-10 and MMP-9." @default.
- W2384905827 created "2016-06-24" @default.
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- W2384905827 date "2011-01-01" @default.
- W2384905827 modified "2023-09-26" @default.
- W2384905827 title "A study on the expression level of IL-10 and MMP-P in non-small cell lung cancer and their correlation with prognosis" @default.
- W2384905827 hasPublicationYear "2011" @default.
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