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- W2384938051 abstract "Objective:To investigate the effects of bFGF gene transfected bone marrow mesenchymal stem cells(BMSCs)in accelerating distraction osteogenesis in rat mandibular.Method:36 adult male SD rats were randomly divided into experimental and control groups,18 in each group.The mandibular DO models were established at right mandibular and normal distraction force were applied.The bFGF gene transfected rMSCs were injected into the distraction gap in each experimental rat,while the same number of empty vector transfected rMSCs in each control rats.The distracted mandibles were harvested 2,4 and 8 weeks respectively after cell injection.Radiographic,histological observation and bone mineral density measurement were performed to evaluate the bone regeneration.Result:Bone regeneration was found in the distraction gap after mandibular lengthening in both groups.The formation rate of new bone and the bone mineral density of the regenerated bone were significantly higher in experimental rats than those in control(P 0.05).Conclusion:bFGF gene transfected bone marrow mesenchymal stem cells can accelerate new bone formation in rat mandibular distraction osteogenesis." @default.
- W2384938051 created "2016-06-24" @default.
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- W2384938051 date "2010-01-01" @default.
- W2384938051 modified "2023-09-24" @default.
- W2384938051 title "Bone regeneration accelerated by bFGF gene transfected bone marrow mesenchymal stem cells in rat mandibular distraction osteogenesis." @default.
- W2384938051 hasPublicationYear "2010" @default.
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