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- W2384944904 abstract "Objective To investigate the effect of tetramethylpyrazine(TMP) on the expression of COX-2 after cerebral ischemic-reperfusion injury in rats.Methods The focal cerebral ischemic-reperfusion model of middle cerebral artery occlusion was established with thread embolish.The expression of cox-2 in cortex,pathological damage of brain tissue and neurologicai function disorders were examined with western bloting,H-E staining and neurological evaluation.Results Compared with ischemic-reperfusion model group(I2h/R24h),the content of COX-2 was decreased significantly,the pathological damage of brain tissue was attenuated and neurologicai function disorders were markedly downregulated in TMP treatment group.Conclusions TMP might restrain the COX-2 expression,attenuate the pathological damage of brain tissue and improve neurological symptoms,possess pretective effect after cerebral ischemic-reperfusion injury." @default.
- W2384944904 created "2016-06-24" @default.
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- W2384944904 date "2011-01-01" @default.
- W2384944904 modified "2023-09-23" @default.
- W2384944904 title "The effect of tetramethylpyrazine on the expression of COX-2 after cerebral ischemic-reperfusion injury in rats" @default.
- W2384944904 hasPublicationYear "2011" @default.
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