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- W2384957718 abstract "Objective: To study the efficacy and the effects of recombinant human brain natriuretic peptide(rhBNP) on aldosterone and endothelin-1 in the treatment of congestive heart failure(CHF). Methods: A randomized, open, controlled clinical trail was conducted in 35 patients with CHF. Eighteen received rhBNP and 17 were treated with nitroglycerin as controls. The changes hemodynamic indexes, the plasma concentrations of K+ , Na+ , aldosterone (ALD) and endothelin-1 ( ET-1) in order to examine the efficacy and mechanism of rhBNP . Results: Between experiment and control groups significant differences were found in the decreasing of PCWP, PAP and plasma concentration of Na+ , ALD, ET-1, and in the increasing of plasma concentration of K + (P 0. 05 - 0. 01). Conclusion; The mechanism of rhBNP may be associated witlh the overactivation of renin-angiotension-aldosterone system, and the inhibited production of endothelin-1." @default.
- W2384957718 created "2016-06-24" @default.
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- W2384957718 date "2007-01-01" @default.
- W2384957718 modified "2023-09-22" @default.
- W2384957718 title "Effects of Recombinant Human Brain Natriuretic Peptide on Aldosterone and Endothelin-1 in Treatment of Heart Failure" @default.
- W2384957718 hasPublicationYear "2007" @default.
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