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- W2384966360 abstract "Objective To explore the expression and clinical significance of myeloid-derived suppressor cells(MDSCs) in peripheral blood in patients with gastrointestinal cancer.Methods The peripheral blood samples were Collected from 20 healthy volunteers(aged 28 to 50 years,mean 36 years) and 59 newly diagnosed patients(aged 27 to 80 years,mean 59 years) with gastrointestinal cancer.The peripheral blood cells from tumor patients and healthy persons were labeled with fluorescent labeled anti-human Lin1,HLA DR,CD33 and CD11b monoclonal antibody.The MDSCs(Lin-/LoHLA DR-CD33+CD11b+) were detected with flow cytometry.Results The percentage(3.99±1.24%) of MDSCs in patients with gastrointestinal cancer was significantly higher than the healthy persons(1.81 ±0.74%,P 0.01);Significant difference existed between metastatic tumors(5.34 ±1.54%) and non-metastatic tumors(3.71±1.46%).There was no statistical significance(P0.05) in MDSCs between patients with gastric cancer(3.57± 1.59%) and patients with colon cancer(4.31±1.71%).There were 19 cases among all cancer patients also suffering from high blood pressure and diabetes.The average level of MDSCs was(3.62±1.16%),and there was no difference when compared with patients of general cancer(P0.05).Conclusion MDSCs increases in gastrointestinal malignant tumor,and more obviously in metastatic tumors,which can be used to determine the severity and prognosis of tumors.But it is not specific in tumors with different tissue source.High blood pressure,diabetes and other basic diseases influence tumors' development slightly in MDSCs." @default.
- W2384966360 created "2016-06-24" @default.
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- W2384966360 date "2013-01-01" @default.
- W2384966360 modified "2023-09-23" @default.
- W2384966360 title "Detection of myeloid-derived suppressor cells in peripheral blood of patients with gastrointestinal cancer" @default.
- W2384966360 hasPublicationYear "2013" @default.
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