Matches in SemOpenAlex for { <https://semopenalex.org/work/W2384984141> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2384984141 abstract "Objective To elucidate the direct effect of brain-derived neurotrophic factor(BDNF) on contraction of mice intestinal muscle strips and to investigate whether the effect of BDNF on intestinal contraction is mediated through the tyrosine kinase receptor B(TrkB)-phospholipase C(PLC)/ inositol triphosphate(IP3) pathway.Methods Longitudinal muscle(LM) strips of ileum,proximal colon and distal colon from C57bl/6 mice were prepared.The contraction of LM was recorded with a tension transducer.To investigate the contractile effect of BDNF on LM strips,two different doses of BDNF(1×10-8 and 1×10-7mol/L) were added to the muscle strips.To investigate the effects of antagonists of the TrkB-PLC/IP3 signal pathway on the contraction of muscle strips induced by BDNF,LM strips were pretreated with TrkB(1×10-8mol/L),neomycin(1×10-5mol/L) and heparin(1×10-5mol/L) before administration of BDNF.Results BDNF excited the contraction of LM from the ileum,proximal colon and distal colon of mice(P0.05).Pretreatment with TrkB(1×10-8mol/L),neomycin(1×10-5mol/L) and heparin(1×10-5mol/L) dramatically attenuated the excitatory effect of BDNF(1×10-7mol/L) on the contraction of LM strips(P0.05).Conclusion BDNF excites the contraction of mice intestinal muscle strips,and the antagonists of the TrkB-PLC/IP3 signal pathway attenuate the excitatory effect of BDNF,which highlights the important role of BDNF and the TrkB-PLC/IP3 signal pathway in promoting the gut motility." @default.
- W2384984141 created "2016-06-24" @default.
- W2384984141 creator A5064468525 @default.
- W2384984141 date "2012-01-01" @default.
- W2384984141 modified "2023-09-26" @default.
- W2384984141 title "Brain-derived neurotrophic factor influences contractile activity in the isolated ileum and colon of mice" @default.
- W2384984141 hasPublicationYear "2012" @default.
- W2384984141 type Work @default.
- W2384984141 sameAs 2384984141 @default.
- W2384984141 citedByCount "0" @default.
- W2384984141 crossrefType "journal-article" @default.
- W2384984141 hasAuthorship W2384984141A5064468525 @default.
- W2384984141 hasConcept C126322002 @default.
- W2384984141 hasConcept C134018914 @default.
- W2384984141 hasConcept C160539049 @default.
- W2384984141 hasConcept C163415756 @default.
- W2384984141 hasConcept C170493617 @default.
- W2384984141 hasConcept C185592680 @default.
- W2384984141 hasConcept C2776050358 @default.
- W2384984141 hasConcept C2777226302 @default.
- W2384984141 hasConcept C2778597717 @default.
- W2384984141 hasConcept C2778790584 @default.
- W2384984141 hasConcept C2779841869 @default.
- W2384984141 hasConcept C501593827 @default.
- W2384984141 hasConcept C55493867 @default.
- W2384984141 hasConcept C71924100 @default.
- W2384984141 hasConcept C86803240 @default.
- W2384984141 hasConcept C97124661 @default.
- W2384984141 hasConceptScore W2384984141C126322002 @default.
- W2384984141 hasConceptScore W2384984141C134018914 @default.
- W2384984141 hasConceptScore W2384984141C160539049 @default.
- W2384984141 hasConceptScore W2384984141C163415756 @default.
- W2384984141 hasConceptScore W2384984141C170493617 @default.
- W2384984141 hasConceptScore W2384984141C185592680 @default.
- W2384984141 hasConceptScore W2384984141C2776050358 @default.
- W2384984141 hasConceptScore W2384984141C2777226302 @default.
- W2384984141 hasConceptScore W2384984141C2778597717 @default.
- W2384984141 hasConceptScore W2384984141C2778790584 @default.
- W2384984141 hasConceptScore W2384984141C2779841869 @default.
- W2384984141 hasConceptScore W2384984141C501593827 @default.
- W2384984141 hasConceptScore W2384984141C55493867 @default.
- W2384984141 hasConceptScore W2384984141C71924100 @default.
- W2384984141 hasConceptScore W2384984141C86803240 @default.
- W2384984141 hasConceptScore W2384984141C97124661 @default.
- W2384984141 hasLocation W23849841411 @default.
- W2384984141 hasOpenAccess W2384984141 @default.
- W2384984141 hasPrimaryLocation W23849841411 @default.
- W2384984141 hasRelatedWork W1489914001 @default.
- W2384984141 hasRelatedWork W1512795414 @default.
- W2384984141 hasRelatedWork W1979778858 @default.
- W2384984141 hasRelatedWork W1987300839 @default.
- W2384984141 hasRelatedWork W1990337791 @default.
- W2384984141 hasRelatedWork W1997585172 @default.
- W2384984141 hasRelatedWork W2016571517 @default.
- W2384984141 hasRelatedWork W2047907027 @default.
- W2384984141 hasRelatedWork W2055106101 @default.
- W2384984141 hasRelatedWork W2063742353 @default.
- W2384984141 hasRelatedWork W2084582210 @default.
- W2384984141 hasRelatedWork W2089295866 @default.
- W2384984141 hasRelatedWork W2092512723 @default.
- W2384984141 hasRelatedWork W2093347690 @default.
- W2384984141 hasRelatedWork W2387634154 @default.
- W2384984141 hasRelatedWork W2391781978 @default.
- W2384984141 hasRelatedWork W2403380352 @default.
- W2384984141 hasRelatedWork W2408858459 @default.
- W2384984141 hasRelatedWork W2897597188 @default.
- W2384984141 hasRelatedWork W3032170186 @default.
- W2384984141 isParatext "false" @default.
- W2384984141 isRetracted "false" @default.
- W2384984141 magId "2384984141" @default.
- W2384984141 workType "article" @default.