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- W2384992249 abstract "Objective To explore the impact of Urokinase(UPA) on cyclosporin A induced inflammation and the expression of snail in rats.Methods CSA gavage was applied for establishment of the disease model and the animals were randomly divided into three groups:control group,CSA group and UPA group.Renal interstitial fibrosis was graded according to Masson staining.Levels of inflammatory factor TNF-were tested using ELISA.Protein expression and distribution of Snail1 were determined by immunohistochemistry and mRNA expression of Snail1 was examined by RT-PCR.Results(1) Collagen deposition was increased in the CSA group compared with the control group but the UPA group showed a significantly reduced level of collagen deposition than the CSA group(P0.05).(2) TNF-α levels were significantly higher in the CSA group than in the control group and significantly lower in the UPA group than in the CSA group(P0.05).(3)Snail protein levels were significantly higher in the CSA group,which mostly located in the nuclei,than in the control group(P0.05) and significantly lower in the UPA group than in the CSA group(P0.05).(4)Snail mRNA levels were significantly higher in the CSA group than in the control group(P0.05) and significantly lower in the UPA group than in the CSA group(P0.05).Conclusion Urokinase alleviates renal fibrosis in in rats with cyclosporin A induced nephropathy and decreases the expression levels of snail." @default.
- W2384992249 created "2016-06-24" @default.
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- W2384992249 date "2011-01-01" @default.
- W2384992249 modified "2023-09-24" @default.
- W2384992249 title "Impact of Urokinase on Expression of Snail in Rats with Renal Interstition Fibrosis and Possible Mechanisms" @default.
- W2384992249 hasPublicationYear "2011" @default.
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