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- W2384995026 abstract "Objective:To study the alteration and significance of ER status in Adriamycin-sen-sitive and Adriamycin-resistant MCF-7human breast cancer cell lines.Methods:The status of ER of MCF-7/ADR and parental MCF-7cells was detected by Western blot.The growth and the sensitivity to Estrogen(E 2 )and droloxifene(Dro)of cells were investigated by MTT assay,and the distribution of cell cycle was detected by flow cytometric assay.Results:ER was positive in MCF-7cells,but negative in MCF-7/ADR cells.In comparison with MCF-7cells,MCF-7/ADR cells showed lower growth rate,and the cell cycle was arrested at G 0 /G 1 phase.E 2 at concentrations between1×10 -12 mol/L and1×10 -7 mol/L significantly stimulated the growth of MCF-7,but did not stimulate the growth of MCF - 7/ADR.Dro at concentrations between10μmol/L and20μmol/L significantly inhibited the growth of MCF-7,and the inhibition was dose-dependent.Dro at concentrations below20μmol/L did not inhibit the growth of MCF-7/ADR,Dro inhibited the growth of MCF-7/ADR only at the concentration of20μmol/L,and the inhibition was more effective than that of MCF-7.Conclusion:ER is lost and the growth rate de-creases in MCF-7/ADR cells,at the same time MCF-7/ADR cells loses the dependence on estrogen and the sen sitivity to endocrine therapy." @default.
- W2384995026 created "2016-06-24" @default.
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- W2384995026 date "2003-01-01" @default.
- W2384995026 modified "2023-09-25" @default.
- W2384995026 title "Alteration and significance of ER status in Adriamycin-sensitive and Adriamycin-resistant MCF-7human breast cancer cell lines" @default.
- W2384995026 hasPublicationYear "2003" @default.
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