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- W2384996441 abstract "Objective To investigate the effect of magnetic fluid hyperthermia (MFH) on the proliferation and apoptosis of human benign meningiomas. Methods The short-term primary culture of the human fresh meningioma cells derived from 15 patients was performed. The third generation cells were once or thrice heated to 42~44 ℃ for 30 minutes by ferric oxide MFH. The cells apoptosis was detected by flow cytometry. The inhibitory rate of the meningiomas cells proliferation was determined by methyl thiazolyl tetrazolium (MTT) assay 1, 2, 3 and 4 days after the treatment with MFH. Results The inhibitory rates of meningioma cells proliferation in once heating (44 ℃, 30 min) group and thrice heating (44 ℃, 30 min) group were (12.62±0.78)% and (12.78±1.56)% respectively 4 days after heating with MFH, which were significantly higher than that in the control group (P0.05). There mainly was timorous cells necrosis in all the heating groups, in which the rates of the cell apotosis were insignificantly different from that in the control group. Conclusion In vitro, the proliferation of human meningiomas cells can be inhibited by heating to 44 ℃ for 30 min with ferric oxide MFH, by which the tumor cell necrosis, not apoptosis can be induced." @default.
- W2384996441 created "2016-06-24" @default.
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- W2384996441 date "2010-01-01" @default.
- W2384996441 modified "2023-09-23" @default.
- W2384996441 title "Effects of ferric oxide magnetic fluid hyperthermia on proliferation and apoptosis of human benign menin-giomas" @default.
- W2384996441 hasPublicationYear "2010" @default.
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