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- W2384996568 abstract "Objective Cerebral ischemia increases the risk of vascular cognitive impairment.The study aimed to compare the cognitive function of patients with partial anterior circulation infarct(PACI) and amnesic mild cognitive impairment(aMCI).Methods Twenty-nine patients meeting the classification criteria of PACI by Oxford Community Stroke Project(OCSP),35 individuals with aMCI by Petersen criteria,and 60 healthy elderly controls were enrolled in this prospective study.Cognitive functions were assessed by Cognitive Ability Screening Instrument-C2.1(CASI) within 1 month after diagnosis.The scores of nine cognitive domains in CASI and the total score of CASI were used for comparisons.Age,education and gender were entered as covariates in the general linear model for comparisons.Results Compared with control group(95.57±3.441),the total scores of CASI were significantly lower in PACI(86.28±12.041) and aMCI groups(89.86±6.030)(F(2)=8.547,P0.05).There was no significant difference in CASI total score between PACI and aMCI groups(P0.05).The scores of attention(P=0.000) and orientation(P=0.021) were markedly lower in PACI group when compared with NC group.Compared with aMCI group,the score of mental calculation(P=0.000) was significantly lower in PACI group.Compared with control group,scores of short-term memory(P=0.000),abstract thinking and judgment(P=0.013),and category fluency(P=0.001) were lower in aMCI group.The score of short-term memory(P=0.016)and category fluency(P=0.005) were also lower in aMCI group than PACI group.Conclusions Individuals with PACI present marked cognitive impairment,especially in attention and orientation.In comparison with aMCI individuals,PACI individuals may preserve executive function as measured with category fluency.The findings suggest that cerebral ischemia-induced cognitive impairment may be in different domains from those induced by neurodegenerative diseases." @default.
- W2384996568 created "2016-06-24" @default.
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- W2384996568 date "2011-01-01" @default.
- W2384996568 modified "2023-09-28" @default.
- W2384996568 title "The study on cognitive functions of patients with partial anterior circulation infarct and amnesic mild cognitive impairment." @default.
- W2384996568 hasPublicationYear "2011" @default.
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