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- W2384996901 abstract "Objective To evaluate the biological safety of PDGF-BB releasing nano-nacre/PDLLA/FG composite scaffolds for providing the scientific and experimental basis for clinical application. Methods Scaffold was immersed into normal saline in order to obtain extracts. Then the extracts were subjected to acute systemic toxicity test, intradermal stimulation test and pyrogen test to evaluate the biological safety. Additionally, the scaffolds were implanted in back subcutaneous tissue to observe its surrounding tissue reaction and evaluate its histocompatibility. Results The results showed that the scaffold was non-toxic,non-stimulation, no pyrogen. After scaffolds were implanted in subcutaneous tissue, the histopathology biopsy confirmed that after the material was implanted in rabbits, the inflammatory cells gradually reduced and surrounding tissue fibers cyst gradually thinned. Conclusion The PDGF-BB releasing nano-nacre/PDLLA/FG composite scaffold possesses good biological safety and histocompatibility and match the basic conditions of bone tissue engineering materials." @default.
- W2384996901 created "2016-06-24" @default.
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- W2384996901 date "2013-01-01" @default.
- W2384996901 modified "2023-09-23" @default.
- W2384996901 title "Biological security evaluation of PDGF-BB releasing nano-nacre/PDLLA/FG composite scaffold" @default.
- W2384996901 hasPublicationYear "2013" @default.
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