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- W2384998514 abstract "Objective To explore the mechanism of injury of acute hypoxia on cardiac myocyte. Methods Thirty six male wister rats were randomly divided into 6 groups ( n =6): 1 control group and 5 experimental groups. Two of experimental groups were injected N Methyl L Arginine (L NAME) before experiment(100 mg/kg). The experimental groups underwent 8 000 m altitude exposure in hypobaric chamber for 30 min, and repeat it after 0 m altitude, and the blood was take out in an experimental group immediately after exposure, and in two experimental groups 6 hour after exposure, and in two experimental groups 24 hour after exposure. The content of nitric oxide (NO) and the active of Asparte Aminotransferase(AST) Lactate Dehydrogenase(LDH) Creatine Kinase(CK) α Hydroxybutyrate Dehydrogenase (α HBDH) in rat blood,and eNOSmRNA, iNOSmRNA expression level in rat heart were measured. Results The level of NO AST LDH CK α HBDH in the experimental groups was significantly higher than that of control group, and the level of the higher was restrain in injected L NAME experimental groups. iNOSmRNA expression level in rat heart was highter and eNOSmRNA expression level was lower after hypoxia exposure. Conclusions iNOS may play an important role in cardiac myocyte injury of acute hypoxia." @default.
- W2384998514 created "2016-06-24" @default.
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- W2384998514 date "2002-01-01" @default.
- W2384998514 modified "2023-09-25" @default.
- W2384998514 title "Change of cardiac enzyme after acute hypoxia explore" @default.
- W2384998514 hasPublicationYear "2002" @default.
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