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- W2384998626 abstract "Objective To establish a stable and reliable infected necrotizing pancreatitis(INP)model in rats to study the pathophysiological mechanism and pathological development rule of INP and explore the new therapeutic methods for the disease.Methods Forty-five SD rats were randomized into 5 groups.The animals in group A received the injection of 5% sodium taurocholate into the pancreatic duct and those in group B underwent that of E coli into the pancreatic duct.The rats in group C,D and E were given the in- jection of 5% sodium taurocholate in combination with different concentrations of E.coli(10~3/ml,10~4/ml and 10~5/ml,respectively)into the pancreatic duct.The dose of injection was 0.lml·100g~(-1)and velocity of injection 0.2ml·min~(-1)in all the 5 groups.Eight hours after the injection,the survival rate of animals was recorded and the surviving rats were killed to determine the serum content of amylase and perform pathologi- cal examination and germ cultivation of the pancreatic tissue.Results Acute necrotizing pancreatitis model was induced by injection of 5% sodium taurocholate into the pancreatic duct.The positive rate of germ culti- vation in group A was 12.5%.The acute necrotizing pancreatitis model was not induced by injection of E.coli into the pancreatic duct and the positive rate of germ cultivation in group B was 0.The INP model was established in groups C to E.The positive rate of germ cultivation was 60%,100% and 100% and 8-h survival rate 100%,100% and 70% in group C,D and E,respectively.Conclusions A stable and reliable model of INP is established by injection of 5% sodium taurocholate in combination with 10~4/ml E.coli into the pancreatic duct with a dose of 0.1ml·100g~(-1)and a velocity of 0.2ml·min~(-1).The pathogenesis of INP might be that the hemorrhage and necrosis of pancreatic tissue induced by sodium taurocholate results in weakness of pancreatic tissue in fighting against the germs.Meanwhile,the necrotic pancreatic tissue pro- vides a good proliferative environment for the germs." @default.
- W2384998626 created "2016-06-24" @default.
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- W2384998626 date "2006-01-01" @default.
- W2384998626 modified "2023-09-24" @default.
- W2384998626 title "Establishment of infected necrotizing pancreatitis model by injection of sodium taurocholate and E coli into pancreatic duct in rats" @default.
- W2384998626 hasPublicationYear "2006" @default.
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