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- W2385004227 abstract "The receptor-binding properties of insulin and its analogs with modified C-terminal peptide sequence of the B-chain have been studied in liver cells and fat cells. The results show that despentapeptide insulin has the same binding capacity as that of insulin; deshexapeptide insulin and its analog with B_(23)-glycine replaced by D-alanine have definite binding effect; desoctapeptide insulin has a very weak binding effect; the A-chain of insulin, ACTH and glucagon do not bind with insulin receptor. On this basis, the possible involvement of B_(24) aromatic ring in the binding site has been discussed and it has been proposed that the hydrophobic surface formed by B_(12), B_(16), B_(24) and B_(25) may be an important element of the binding site and the B_(20)-B_(23) U turn and A_(21)... B_(22) salt linkage may have a stabilizing effect on the hydrophobio structure, and that the binding of insulin with the receptor protein may be similar to the formation of the insulin dimer from the two monomers." @default.
- W2385004227 created "2016-06-24" @default.
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- W2385004227 date "1975-01-01" @default.
- W2385004227 modified "2023-09-28" @default.
- W2385004227 title "STUDIES ON THE MECHANISM OF INSULIN ACTION I. THE INTERACTIONS OP INSULIN AND ITS ANALOGS WITH INSULIN RECEPTOR" @default.
- W2385004227 hasPublicationYear "1975" @default.
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