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- W2385016874 abstract "Objective To investigate the effect of celecoxib on proliferation and apoptosis of human gastric carcinoma (GC) cell line as well as the growth of GC xenografts in nude mice.Methods SGC7901 cells were treated with celecoxib at serial concentrations of 25,50,100, and 200 μmol/L.The proliferative status of SGC7901 was measured by using methabenzthiazuron(MTT) assay. Cell cycle was determined using Flow Cytometry(FCM) analysis. Nude mice bearing xenografis of the cell line were treated with celecoxib daily until six weeks after tumor implantation. Results After SGC7901 cells were exposed to celecoxib (25,50,100, and 200μmol/L) for 24, 48, 72, 96 h, celecoxib displayed a strong growth effect in a dose-and time-dependent manner against SGC7901 cells. After exposure of the cells to 50 μmol/L celecoxib for 12h, FCM analysis showed the G0/G1 phase ratio increased, and S and G2/M phase ratio decreased. The apoptosis rate was higher in treat ment group than that in control group( 20.44±2.8 % vs 7.6 4±0.6%,P0.05). At necropsy, in mice given celecoxib, the mean tumor weight were significantly lower than that in control group [(0.43±0.21) g vs (1.334±0.45) g, P0.05].Conclusions Celecoxib can effectively inhibit the growth of GC both in vivo and in vitro. The mechanisms of antineoplastic effect action may involved in inhibiting various phases of cell cycle kinetics and inducing apoptosis of tumor cells." @default.
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- W2385016874 date "2005-01-01" @default.
- W2385016874 modified "2023-09-23" @default.
- W2385016874 title "Inhibition effects of celecoxib on the growth of gastric carcinoma in vitro and in vivo" @default.
- W2385016874 hasPublicationYear "2005" @default.
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