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- W2385017709 abstract "Objective: To study the effect of electroacupuncture(EA) of Dazhui(GV 14) and Mingmen(GV 4) on hypothalamic corticotrophin releasing hormone(CRH),plasma adrenocorticotropic hormone(ACTH),serum cortisol(Cort) and tumor necrosis factor(TNF)-α contents in adjuvant arthritis rats.Methods: Thirty-six male Wistar rats were evenly randomized into normal control,model,EA-GV14 and EA-GV4 groups.Arthritis model was established by subcutaneous injection of Freund's complete adjuvant(FCA,(0.1 mL)) into the right hind-paw.EA((15 Hz),continuous pulses,(1 mA)) was applied to Dazhui(GV 14) and Mingmen(GV 4) for(20 min),once every other day and continuously for 8 times.After the rats were killed,hypothalamic tissue and blood sample were taken for detecting hypothalamic CRH,plasma ACTH,serum Cort and TNF-α contents with radioimmunoassay.Results: Compared with normal control group,the swelling rate of the right hindpaw(24 h) after injection of FCA and 16 days after EA increased significantly(P0.01);while in comparison with model group,the swelling rates of EA-GV14 and EA-GV4 groups were markedly lower(P0.01).Compared with normal control group,hypothalamic CRH,plasma ACTH,serum Cort and TNF-α contents of model group increased significantly(P0.05);while in comparison with model group,hypothalamic CRH serum Cort and TNF-α contents in EA-GV14 group,and serum Cort level in EA-GV4 group decreased significantly(P0.05).No significant differences were found between EA-GV14 and EA-GV4 groups(P0.05) in these 4 indexes.Conclusion: EA has a marked anti-inflammatory effect in adjuvant arthritis rats and can relieve arthritis stress induced increase of hypothalamic CRH,plasma ACTH,serum Cort and TNF-α levels." @default.
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- W2385017709 date "2006-01-01" @default.
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- W2385017709 title "Influence of Electroacupuncture of Dazhui(GV14) and Mingmen(GV4) on Stress-related Factors in Adjuvant Arthritis Rats" @default.
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