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- W2385023924 abstract "Objective To study the effect of captopril and valsartan on expression of matrix metalloproteinase-2(MMP-2) and tissue inhibitor of metalloproteinase-2(TIMP-2) in kidney tissue of atherosclerotic rabbit.Methods Thirty male new zealand white rabbits were divided into four groups randomly:(A group)cholesterol group,(B group) cholesterol+ captopril treated group,(C group) cholesterol+ valsartan treated group and(D group)control group.After 10 weeks, the expression of MMP-2 and TIMP-2 in renal tissue were examined by immunohistochemisrtry.Results Compared with control group,MMP-2 level of renal tissue in A group was decreased significantly.Captopri increased MMP-2,but the level of MMP-2 was still lower than that of control group.Also valsartan increased MMP-2,and there were no significant difference between the level of MMP-2 in C group and D group.TIMP-2 level of renal tissue in A group increased significantly compared to D group.Captopril and valsartan decreased the expression of TIMP-2 respectively.And there were no difference between B group and D group,C group and D group,and B group and C group.Conclusion The changes of the expression of MMP-2 and TIMP-2 in kidney tissue of atherosclerotic rabbit may be concerned with RAS activating.Captopril or valsartan could decreased the expression of those factors,so could ameliorate the lesions of renal injury through interruping RAS activiation." @default.
- W2385023924 created "2016-06-24" @default.
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- W2385023924 date "2006-01-01" @default.
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- W2385023924 title "Effect of captopril and valsartan on expression of MMP-2 and TIMP-2 in kidney tissue of atherosclerotic rabbit" @default.
- W2385023924 hasPublicationYear "2006" @default.
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