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- W2385026596 abstract "[Objective] To investigate the possible protective role of propofol on apoptotic cell death and expressions of Bcl-2 and Bax gene proteins in a model of torsion/detorsion of the rat testis.[Methods] Thirty adolescent male Wistar rats were randomized into three groups of ten rats each.Group1 the left testis underwent a clockwise 720° torsion then untwisted at once as a control;in group 2,3 the left testis underwent a clockwise 720° torsion for 2 h followed by detorsion;in group 3 propofol was dripped intravenously 5 min before the left testicular detorsion and then kept 1 h.24 h after operation,left testis was removed and assessed for cell apoptosis and expressions of Bcl-2 and Bax by TUNEL technique and immunohistochemical method respectively.[Result] In group 2,the germ cell apoptotic index and Bax expression of the testis were significantly increased compared with those in group1(P 0.01),while Bcl-2 expression decreased obviously(P 0.01),the ratio of bcl-2/Bax decreased and the pathological lesions of the testicle were obvious.The changes mentioned above were alleviated obviously in group 3 compared with those in group 2(P 0.01).[Conclusions] Propofol can suppress the apoptosis of germ cells induced by testicular torsion/detorsion through its regulation of Bcl-2 and Bax gene protein expressions,which may be important for protecting the testis from torsion/detorsion injury." @default.
- W2385026596 created "2016-06-24" @default.
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- W2385026596 date "2005-01-01" @default.
- W2385026596 modified "2023-09-25" @default.
- W2385026596 title "Effects of propofol on apoptosis of rat testicular germ cells and expressions of Bcl-2 and Bax gene induced by testicular torsion/detorsion" @default.
- W2385026596 hasPublicationYear "2005" @default.
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