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- W2385027375 abstract "OBJECTIVE:To establish the method for the LC-MS determination of rosuvastatin concentration in human plasma.METHODS:After liquid-liquid extraction with aether-dichloromethane(3∶2),LC-MS method was adopted.The determination were separated on a Shim-Pack VP-ODS column with the mobile phase consisted of methanol-5 mmol·L~(-1)ammonium acetate solution(containing 0.5% formic acid)(65∶35)at a flow rate of 0.3 mL·min-1.Detection was carried out by electrospray positive ionization mass spectrometry in the multiple reaction monitoring(MRM)mode.The MRM transitions of m/z 482.2→258.2 and m/z 748.5→158.4 were used to quantify rosuvastatin and I.S.,respectively.RESULTS:Rosuvastatin and I.S.were eluted for 3.49 min and 2.70 min,respectively.The calibration curve was linear in the range of 0.050 0 ng·mL-1～30.0 ng·mL~(-1)(r=0.996 2)with the lower limit of quantitation(LLOQ)of 0.050 0 ng·mL~(-1).Intra-day and inter-day RSD were both less than 11%.Mean extraction recoveries were(89.7±3.6)%.In the stability studies,rosuvastatin in plasma was found to be stable under various storage conditions.CONCLUSION:It is a rapid,sensitive,selective and reliable method for the determination of rosuvastatin concentration in human plasma.The method is suitable for bioequivalence study of rosuvastatin calcium preparations in human subjects." @default.
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- W2385027375 date "2011-01-01" @default.
- W2385027375 modified "2023-09-25" @default.
- W2385027375 title "Determination of Rosuvastatin Concentration in Human Plasma by LC-MS Method" @default.
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