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- W2385034461 abstract "Objective To investigate the possible mechanism of c-myc antisense oligodexynucleotide (ASODN) against malignant melanoma cells.Methods C-myc ASODN was synthesized and transfected into melanoma cell line A375. The viability of the cells was determined by the trypanblue exclusion test.Cell cycle was determined by flow cytometry.HLA-Ⅰexpression was examined by indirect immunofluorescence flow cytometry. Results The proliferation of A375 cells exposed to 30 μmol/L ASODN was decreased as compared to control group and SODN group.Cell cycles were blocked in G 1stage.The expression of HLA-Ⅰantigen was up-regulated by ASODN.Conclusion The inhibitory effect on malignant melanoma cells may be performed by the antiproliferation of c-myc ASODN and the up-regulation of HLA-Ⅰexpression by c-myc ASODN." @default.
- W2385034461 created "2016-06-24" @default.
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- W2385034461 date "2005-01-01" @default.
- W2385034461 modified "2023-09-23" @default.
- W2385034461 title "Preliminary Study on the Mechanism of C-myc Antisense Oligodexynucleotide against Malignant Melanoma Cells" @default.
- W2385034461 hasPublicationYear "2005" @default.
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