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- W2385043223 abstract "Objective To investigate the perspective of clinical application of rAd5/p53 and its synergetic role with vascular endothelial growth factor antibody Bevacizumab(Avastin)in osteosarcoma of nude mice.Methods The osteosarcoma model was established by using human osteosarcoma cell line 9901.Sixteen mice were randomly divided into four groups:control group,rAd5/p53 group,Avastin group and combination group treated with Avastin and rAd5/p53.The tumor volumes were measured and the tumor inhibition rate was calculated after two-week treatment.Meanwhile microvessel density(MVD),proliferation index(PI)and apoptotic index(AI)were detected by immunohistochemical staining.Results Tumor growth was significantly inhibited in all the treatment groups.The tumor inhibition rates were 38.10%,32.87% and 76.93% in rAd5/p53 group,Avastin group and combination group respectively.The MVD and PI in rAd5/p53 group,Avastin group and combination group were significantly lower than the control group.The MVD and PI in combination group were significantly lower than rAd5/p53 group and Avastin group(P0.01).The AI in rAd5/p53 group,Avastin group and combination group were significantly higher than the control group,and the AI in combination group was significantly higher than other treatment groups.Conclusion Avastin and rAd5/p53 may inhibit the angiogenesis of osteosarcoma and cell proliferation,induce cell apoptosis and have a synergistic inhibition in osteosarcoma of nude mice." @default.
- W2385043223 created "2016-06-24" @default.
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- W2385043223 date "2009-01-01" @default.
- W2385043223 modified "2023-09-23" @default.
- W2385043223 title "Inhibitory Effect of Vascular Endothelial Growth Factor Antibody Bevacizumab Combined with rAd5/p53 on Osteosarcoma in Nude Mice" @default.
- W2385043223 hasPublicationYear "2009" @default.
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