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- W2385079884 abstract "AIM To examine if the calcium channel blocker, verapamil, would affect the level of brainstem microsomal protein phosphorylation after administration of tri o cresyl phosphate(TOCP), by which maybe indicate some clues to the pathogenesis of organophosphate induced delayed polyneuropathy(OPIDP). METHODS Verapamil(7 mg·kg -1 ·d -1 , im) was given for 4 d (d 1-d 4) . A dose of TOCP(750 mg·kg -1 ) was administrated by ig on d 2. Phosphorylation of brainstem microsomal proteins was assayed in vitro by using [γ 32 P]ATP as phosphate donor. Radiolabeled proteins were separated by sodium dodecyl sulfate polyacrylamide gel electrophoresis and visualized by autoradiography. The changes of the protein phosphorylation were quantified by densitometry. RESULTS TOCP administration enhanced the phosphorylation of the microsomal proteins with apparent molecular weights of 45, 41, 32 ku by 119%, 174%, 173%, respectively. Verapamil abolished the enhancement induced by TOCP. CONCLUSION The mechanism of calcium channel blocker to ameliorate organophosphate induced delayed polyneuropathy might be the protection of the brainstem microsomal proteins from enhancement of phosphorylation." @default.
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- W2385079884 date "2002-01-01" @default.
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- W2385079884 title "Effects of verapamil on brainstem microsomal protein phosphorylation in vitro in hens dosed with tri-o-cresyl phosphate" @default.
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