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- W2385090044 abstract "Objective To find a more reasonable and effective treatment mod ality for lung metastasis in nasopharyngeal carcinoma by analyzing the results a nd prognosis factors. Methods From January 1988 to July 2003, 60 patients with lung metastasis from nasopharyngeal carcinoma were treated in our hospital, wit h incidence, time, modality as well as immediate and remote results analyzed. Su rvival was calculated by Kaplan-Meier method. The difference of survival betwee n different modalities was evaluated by logrank test. The difference in response rates among different modalities was evaluated by χ2 test. Re sults Most of t he patients had multiple lesions in the bilateral lung(81.7%). About 45%(27 /60 )of the patients would develop multi-organ metastases during their life, and 9 6 .3% of these multi-organ lesions would appear within 9 months after lung metast a sis. The overall 3- and 5-year survival rates were 35.0% and 30.2% respectivel y. The response rate of radiotherapy for the lung metastasis was much better than chemotherapy(P=0.033). The most promising overall survival was o btained with who le lung irradiation plus local boost irradiation and followed by supplementary a djuvant chemotherapy(P=0.002). Conclusions Radiotherapy is one o f the most ef fective treatment for lung metastasis from nasopharyngeal carcinoma in the follo wing conditions: 1. Lung metastasis without loco-regional recurrence, 2. Only one lesion in the lung, therefore, we may irradiate the lesion with a local sma ll f i eld, 3. For patients having multi-lesions in the lung but nolocoregional recurr en ce, the best choice is whole lung plus local boost followed by adjuvant chemothe rapy, and 4. For patients with multi-organ metastases, chemotherapy seems manda tory." @default.
- W2385090044 created "2016-06-24" @default.
- W2385090044 creator A5030203868 @default.
- W2385090044 date "2005-01-01" @default.
- W2385090044 modified "2023-09-23" @default.
- W2385090044 title "The results and prognosis of different treatment for lung metastasis from nasoph aryngeal carcinoma :analysis of 60 patients" @default.
- W2385090044 hasPublicationYear "2005" @default.
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