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- W2385111903 abstract "Objective To investigate the expression of midkine in the peripheral blood of patients with esophageal squamous cell carcinoma(ESCC) and to analyze its relationship with clinicopathological features.Methods Nested RT-PCR was used to detect midkine mRNA in the peripheral blood from 54 patients with ESCC.The peripheral blood from 10 healthy volunteers and 10 specimens surgically removed out of ESCC were served as controls.Results The positive rate of midkine mRNA in 54 patients with ESCC was 61.11 %(33/54),and the mRNA expression of midkine was significantly correlated with lymph node metastasis of ESCC(P0.05).But none of the peripheral blood samples was positive in 10 healthy volunteers.Conclusions The detection of midkine mRNA in peripheral blood from patients with ESCC using nested RT-PCR is highly sensitive and specific for the determination of ESCC.The method established may serve as a useful objective parameter for identifying the malignant behavior,metastasis,recurrence and therapeutic efficacy of ESCC." @default.
- W2385111903 created "2016-06-24" @default.
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- W2385111903 date "2007-01-01" @default.
- W2385111903 modified "2023-09-22" @default.
- W2385111903 title "Expression of midkine mRNA and its clinical significance in the peripheral blood of patients with esophageal squamous cell carcinoma" @default.
- W2385111903 hasPublicationYear "2007" @default.
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