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- W2385114472 abstract "Objective To investigate the reversal of multidrug-resistance (MDR) by hyperthermia at 42.5 ℃ in breast cancer cell line. Methods The breast cancer cell line MCF-7/ADR was heated at 42.5 ℃ for 0.5 h. The cell survival rate and IC50 of treated and untreated cells were measured by MTT test. The expression of MDR1 gene was detected by Real-time PCR,and the expression of P-gp on the surface of cells was detected by flow cytometry. Results Although the obvious alteration of cell growth was not found by colony forming test and cell cycle assay after hyperthermia,the IC 50 of MCF-7/ADR treated with ADM,5-FU and CTX was markedly decreased respectively. Although the expression of mdr1 gene was detected in heated cells by Real-time PCR,the expression of P-gp reduced significantly using FCM. Conclusions Hyperthermia at 42.5 ℃ partly reverses multidrug-resistance of the breast cancer cell line MCF-7/ADR. The possible mechanism is that hyperthermia down-regulates the expression of P-gp at protein post-translation level. The present study could open a new field for hyperthermia utilization in clinical chemotherapy." @default.
- W2385114472 created "2016-06-24" @default.
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- W2385114472 date "2007-01-01" @default.
- W2385114472 modified "2023-09-26" @default.
- W2385114472 title "Modulatory effect of hyperthermia on multidrug-resistance of breast cancer cell" @default.
- W2385114472 hasPublicationYear "2007" @default.
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