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- W2385139426 abstract "OBJECTIVE:The study focused on the correlation between PET-CT signs with the expression of Survivin(an inhibitor of apoptosis protein) and clinicopathological characteristics in non-small cell lung cancer(NSCLC).METHODS: Thirty-three cases of non-small cell lung cancer confirmed by pathology were examined with 2-deoxy-18F-fluoro-D-glucose(18F-FDG) PET before operation.The expression of Survivin was evaluated by immunohistochemical assay in 33 NSCLC tumor samples.The maximum standarized uptake value(SUVmax),Survivin and eight clinicopathological factors were analyzed respectively.RESULTS: The mean of SUVmax in 33 NSCLC was 10.5 ± 5.4.The correlation between SUVmax and histological type(r=0.432,P=0.012),clinical type(r=0.379,P=0.029),size of lesion(r=0.743,P=0.000) were significant in the entire group;the positive expression rate of Survivin was 84.8%(28/33).It is higher in adenocarcinoma than that in squmous cell carcinoma(u=2.29,P=0.022);SUVmax showed no relation to the expression of Survivin,age,gender,differentiation,TNM stage and lymph node metastasis.CONCLUSION: SUVmax is correlated with histopathological type,clinical type and size of lesion,the correlation between Survivin and histological type was significant,but SUVmax showed no relation to the expression of Survivin." @default.
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- W2385139426 date "2011-01-01" @default.
- W2385139426 modified "2023-09-28" @default.
- W2385139426 title "Correlation between ~(18)F-FDG PET-CT signs with the expression of Survivin and clinicopathological factors in non-small cell lung cancer tissues" @default.
- W2385139426 hasPublicationYear "2011" @default.
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