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- W2385140461 abstract "Objective Simulating injury mechanism in human peripheral nerve, acute sciatic nerve crush injuries model was produced in rabbits to investigate the relationship between the manifestations of MRI and pathology in order to provide the information for clinical therapy and operative plan . Methods Thirty-two adult rabbits were randomly divided into two groups: group A (n=16) and B (n=16).In group A, the left sciatic nerves were crushed with a stress of 3.61 kg;In group B, with a stress of 10.50 kg.4 time intervals in each group were observed in 1, 2, 4, and 8 weeks, respectively, and each time interval contained 4 rabbits.Left sciatic nerves were served as injured sides, right sciatic nerves were regarded as control sides.MRI was performed at different time interval after crush injury.Then the nerves were examined pathologically.Results There were no obvious changes on T_1WI in injured sides, but the injured distal segment of sciatic nerve thickened and twisted, showing high signal intensity on 3D T_2WI, T_2WI/SPIR, B-FFE, and T_2WI/STIR.MRI could show abnormality of 30 sciatic nerves, the correct diagnostic rate was 93.75% and false negative rate was 6.25%.The distal sciatic nerve/muscle signal intensity ratio (SIR) of the injured sides was significantly higher than that of the control sides (P0.001).However, there was no difference in SIR between group A and group B (P0.05).SIR in injured side increased at 1 week, reached the peak at 2 weeks, at this time, nerve axons disappeared and lots of myelin degenerated, abduction function disappeared.SIR decreased during 4～8 weeks, the myelin sheath breakdown and Schwann cell proliferated obviously, and abduction functions were observed.The control sciatic nerves showed no abnormality in MRI and pathology. Conclusion MRI can make the diagnosis of crush injury of sciatic nerve, and dynamic SIR measurement of nerve injury correlates well with the pathological and functional recovery process.MRI is an effective method to monitor degeneration, regeneration, and prognosis after injuries." @default.
- W2385140461 created "2016-06-24" @default.
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- W2385140461 date "2004-01-01" @default.
- W2385140461 modified "2023-09-23" @default.
- W2385140461 title "Acute sciatic nerve crush injuries in rabbits:MRI and pathological comparative study" @default.
- W2385140461 hasPublicationYear "2004" @default.
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