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- W2385149020 abstract "【Objective】 To study the expression of V-ATPase in the hepatocellular carcinoma and its relationship with invasion and metastasis of hepatocellular carcinoma.【Methods】 The expression of mRNA and protein were detected by RT-PCR and immunohistochemistry;the migration changes of cancer cells were observed by migration experiment in vitro when BafilomycinA1 was put into the culture medium.【Result】 The expression of mRNA and protein of V-ATPase in hepatocellular carcinoma tissues were much higher than para-carcinoma tissues and normal hepatic tissues.The ability to migrate became low when BafilomycinA1 was added to culture medium.【Conclusion】 V-ATPase was of high expression and was related with metastasis of hepatocellular carcinoma,Bafilomycin A1 can inhibit V-ATPase and interfere with pumping H+ from cancer cells and weaken the ability of migration of cancer cells." @default.
- W2385149020 created "2016-06-24" @default.
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- W2385149020 date "2011-01-01" @default.
- W2385149020 modified "2023-09-23" @default.
- W2385149020 title "Expression of vacuolar-type H(+)-ATPase and it's relationship with the invasion and metastasis of hepatocellular carcinoma" @default.
- W2385149020 hasPublicationYear "2011" @default.
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