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- W2385157682 abstract "Shorted glucagon-like peptide-1( sGLP-1) not only stimulate proliferation of pancreatic beta cells and decrease blood glucose,but also has a longer half-life. This make sGLP-1 has become a potential new drug in the future. In order to elucidate the function of sGLP-1,this study investigates the conformation of sGLP-1 in different conditions by circular dichroism spectrum and fluorescence spectrum. The conformations of sGLP-1 in phosphate buffer are mostly unordered structure and very low helix,and are mostly α-helix in phosphate buffer containing SDS or TFE. Temperature and pH values of solutions have great influences on the conformation of sGLP-1. sGLP-1 preserve the critical residues which are responsible for binding and activating receptor,Induced by receptor,sGLP-1 can form the correct conformation which can bind and activate receptor in vivo,then realize its function. The results show that appropriately truncate C-terminal segment of GLP-1, may obtain long-term and high efficiency GLP-1 analogues." @default.
- W2385157682 created "2016-06-24" @default.
- W2385157682 creator A5015057909 @default.
- W2385157682 date "2010-01-01" @default.
- W2385157682 modified "2023-09-25" @default.
- W2385157682 title "Conformation Research of Shorted Glucagon-like Peptide-1" @default.
- W2385157682 hasPublicationYear "2010" @default.
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